3D Genome and Epigenetics lab
Spatial Transcriptomics
We use multiplexed smRNA-FISH to assay changes in gene expression during development in mouse embryos and gastruloids
Optical Reconstruction Of Chromatin Architecture
We trace chromatin conformations in cells and tissues to understand the biophysical processes underlying genome organization
Measuring the feedback between Chromatin folding and epigenetic state
Our ultimate goal is to disentangle the complex relationship between epigenetics and genome organization and how epigenetic systems use 3D genome organization to encode cellular memory during development.
