Our Science
Tools that we use:
superresolution microscopy
spatial transcriptomics
genomics
genome engineering
biophysical modeling
Questions we seek to answer:
How does a dynamic nuclear environment encode stable gene expression programs?
How does 3D genome organization regulate epigenetic memory?
How do subtle changes in genome organization lead to large changes in gene expression in a context-dependent manner?
How do the proteins that regulate epigenetic systems interact with chromatin to alter genome folding?
